A diet high in saturated and total fats has been linked to a greater risk for developing specific types of breast cancers, including the most common tumorous growths driven by estrogen.
The wildly popular diet was associated with greater risk
for breast cancers fuelled by the hormones estrogen and progesterone, as
well as human epidermal growth factor 2 receptor-negative disease, or
HER2 disease, according to researcher Sabrina Sieri, of Fondazione IRCCS
Istituto Nazionale Dei Tumori in Milan.
The findings were published Wednesday in the Journal of the National Cancer Institute.
In the study, Sieri and her colleagues analyzed data from
more than 10,000 breast cancer patients followed for about a dozen years
after treatment.
Those women had participated in the EPIC longitudinal
study of 337,000 women living in 10 European countries.
The diverse
study group allowed researchers to compare the effects of dietary fat on
women of varying genetic backgrounds.
To compensate for the limitations of self-reported data,
the researchers conducted follow-up interviews by telephone with a
random sampling of eight percent of those in the study group.
Specifically, they found that a diet higher in total fat was associated
with an increased risk of estrogen receptor-positive and progesterone
receptor-positive cancers, while greater total and saturated fat
consumption also increased the risk for HER2 disease.
“A high-fat diet increases [breast cancer] risk and, most
conspicuously, that high saturated fat intake increases risk of
receptor-positive disease, suggesting saturated fat involvement in the
etiology of receptor-positive” breast cancer,” the authors wrote in the study.
Past attempts to study this association had yielded
conflicting results as scientists had trouble collecting accurate
dietary information from study volunteers who also tended to consume fat
at similar levels within a given geographic area — making genetic
comparisons less illuminating, Sieri says.
Such efforts to study breast cancer pathogenesis had also
been hampered by problems with data collection related to the
stratification of breast cancer into the three subtypes, each with its
own prognosis and risk profiles, confounding many a researcher.
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