Drug Shrinks Ovarian Tumours in Early Trial ~ Health Care, Slimming Tips, Nutrition, News, Fitness and Lots..........

A new treatment for ovarian cancer has shown a "very promising" results in women at the advanced stage of the disease.

It shrinks tumours in around half of women who took part in a small trial. Researchers had only been testing the drug to see if it was safe for humans to take, but found it had an almost instant clinical effect.

It is hoped that the drug could help women who have stopped responding to all other current available treatments.

So far, it has only been tested in 15 women, and the researchers say it may not be safe to take for more than a few months.

However, ovarian cancer is a difficult disease to treat, and the prognosis in the advanced stages is very poor.

ONX-0801 is the first in a new class of drugs which work by mimicking the ability of folic acid selectively to latch on to cancer cells, while leaving healthy tissue alone, thus reducing the side-effects often seen with traditional chemotherapy, such as infections, diarrhoea, nerve damage and hair loss.

Once locked on to a cancer cell, the drug disrupts its chemistry by blocking the action of a key molecule, causing widespread DNA damage and cell death.

The researchers, who hope to carry out bigger clinical trials as soon as possible, have also developed a test that can detect which women are most likely to benefit from the treatment.

Study leader Dr Udai Banerji said: "The results we have seen in this trial are very promising. It is rare to see such clear evidence of reproducible responses in these early stages of drug development.

"The beauty of this particular drug is that it is targeted to the cancer cell. This means there are fewer side-effects, making it a kinder treatment for ovarian cancer patients.

"It's early days of course, but I'm keen to see this treatment assessed in later-stage clinical trials as soon as possible."

"The next steps will be for researchers to test the drug in larger clinical trials to confirm it works and is safe, and to work out which women with ovarian cancer this drug could help."

Prof Michel Coleman, of the London School of Hygiene & Tropical Medicine, urged caution.
He said: "Shrinkage of tumours is important, but as the authors point out, that is not the same as producing the hoped-for extension of survival for women with ovarian cancer.

"The excitement of the investigators is completely understandable, but one should be cautious about interpreting this result as a breakthrough for ovarian cancer patients until data on longer-term outcomes are available."

The results of the trial were presented at the American Society of Clinical Oncology annual meeting in Chicago on Saturday.

Ovarian cancer:

The symptoms of ovarian cancer can be vague, and, as a result, the disease is not picked up until the latter stages in around six out of 10 women

In about one in five cases the diseases isn't diagnosed until it is incurable
There were 7,378 new cases of ovarian cancer in the UK in 2014 and more than 4,000 women died from the disease