The global number of new cases of cancer are expected to grow by around 70 percent in the next 20-30 years.
There are various treatment options available for cancer, but they are not always effective; most of them are toxic, and they tend to have a variety of side effects.
In some more aggressive cases, the cancer does not respond to treatment, and it is believed that cancer stem like cells are the reason why the cancer resurface.
Vitamin C up to 10 times more effective than experimental drugs
The researchers measured the impact of seven substances: the clinical drug stiripentol, three experimental drugs (actinonin, FK866, and 2-DG), and three natural substances (caffeic acid phenyl ester (CAPE), silibinin, and ascorbic acid (vitamin C).The research focused on the bioenergetic processes of CSCs, which enable the cells to live and multiply. The study aimed to disrupt the CSCs' metabolism and ultimately prevent their growth.
Of all the substances tested, the team found that actinonin and FK866 were the most effective. However, the natural products were also found to prevent the formation of CSCs, and vitamin C was 10 times more effective than the experimental drug 2-DG.
Additionally, the study revealed that ascorbic acid works by inhibiting glycolysis - the process by which glucose is broken down within the cell's mitochondria and turned into energy for the cell's proliferation.
CREDIT: WIKI
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